PET examination of the monoamine transporter with [11c]β‐CIT and [11c]β‐CFT in early parkinson's disease
Identifieur interne : 002300 ( Main/Exploration ); précédent : 002299; suivant : 002301PET examination of the monoamine transporter with [11c]β‐CIT and [11c]β‐CFT in early parkinson's disease
Auteurs : Juha O. Rinne [Finlande] ; Arto Laihinen [Finlande] ; Kjell N Gren [Finlande] ; Hanna Ruottinen [Finlande] ; Ulla Ruotsawnen [Finlande] ; Urpo K. Rinne [Finlande]Source :
- Synapse [ 0887-4476 ] ; 1995-10.
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Abstract
The monoamine transporter was studied in 4 healthy controls and 5 patients with early Parkinson's disease (PD), who had not received any antiparkinsonian medication, by means of positron emission tomography (PET) using two novel ligands, [11C]β‐CIT and [11C]β‐CFT. Both ligands showed highest uptake in the striatum. There was intermediate accumulation of activity in the thalamus and midbrain, which was more marked for [11C]β‐CIT than for [11C]β‐CFT. In the cortical areas, uptake of both ligands was not different from that seen in the cerebellum. In the controls, the putamen‐to‐cerebellum and caudate‐to‐cerebellum ratios for [11C]β‐CFT were higher than those for [11C]β‐CIT (putamen: 3.15± 0.39 for [11C]β‐CFT, and 1.84 ±0.10 for [11C]CIP‐CIT caudate: 3.15±0.31 for [llC]P‐CFT, and 1.95±0.17 for [11C]β‐CIT). Reduction from mean control value in PD patients was greater for [11C]β‐CFT (45% in the putamen contralateral to the predominant symptoms, P < 0.001) than for [11C]β‐CIT(20%, P > 0.05). [11C]β‐CFT uptake in the caudate nucleus was also diminished in PD patients (to 80% of the control mean, P < 0.05), whereas [11C]β‐CIT was within normal range (reduced to 90% of the control mean). These results indicate that both [11C]β‐CIT and [11C]β‐CFT are useful PET ligands to study brain monoamine transporter in healthy controls and in patients with PD. However, [11C]β‐CFT seems superior to [11C]β‐CIT in this respect. © 1995 Wiley‐Liss, Inc.
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DOI: 10.1002/syn.890210202
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Rinne</name><affiliation wicri:level="3"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Turku University Cyclotron‐PET Center, University of Turku, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Synapse</title><title level="j" type="abbrev">Synapse</title><idno type="ISSN">0887-4476</idno><idno type="eISSN">1098-2396</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1995-10">1995-10</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="97">97</biblScope><biblScope unit="page" to="103">103</biblScope></imprint><idno type="ISSN">0887-4476</idno></series><idno type="istex">47931453C0F058A92648522C3A3F1A4652E9E346</idno><idno type="DOI">10.1002/syn.890210202</idno><idno type="ArticleID">SYN890210202</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0887-4476</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CFT</term><term>CIT</term><term>Dopamine reuptake sites</term><term>Monoamine transporter</term><term>Parkinson's disease</term><term>Positron emission tomography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The monoamine transporter was studied in 4 healthy controls and 5 patients with early Parkinson's disease (PD), who had not received any antiparkinsonian medication, by means of positron emission tomography (PET) using two novel ligands, [11C]β‐CIT and [11C]β‐CFT. Both ligands showed highest uptake in the striatum. There was intermediate accumulation of activity in the thalamus and midbrain, which was more marked for [11C]β‐CIT than for [11C]β‐CFT. In the cortical areas, uptake of both ligands was not different from that seen in the cerebellum. In the controls, the putamen‐to‐cerebellum and caudate‐to‐cerebellum ratios for [11C]β‐CFT were higher than those for [11C]β‐CIT (putamen: 3.15± 0.39 for [11C]β‐CFT, and 1.84 ±0.10 for [11C]CIP‐CIT caudate: 3.15±0.31 for [llC]P‐CFT, and 1.95±0.17 for [11C]β‐CIT). Reduction from mean control value in PD patients was greater for [11C]β‐CFT (45% in the putamen contralateral to the predominant symptoms, P < 0.001) than for [11C]β‐CIT(20%, P > 0.05). [11C]β‐CFT uptake in the caudate nucleus was also diminished in PD patients (to 80% of the control mean, P < 0.05), whereas [11C]β‐CIT was within normal range (reduced to 90% of the control mean). These results indicate that both [11C]β‐CIT and [11C]β‐CFT are useful PET ligands to study brain monoamine transporter in healthy controls and in patients with PD. However, [11C]β‐CFT seems superior to [11C]β‐CIT in this respect. © 1995 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Finlande occidentale</li></region><settlement><li>Turku</li></settlement></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name></region><name sortKey="Laihinen, Arto" sort="Laihinen, Arto" uniqKey="Laihinen A" first="Arto" last="Laihinen">Arto Laihinen</name><name sortKey="N Gren, Kjell" sort="N Gren, Kjell" uniqKey="N Gren K" first="Kjell" last="N Gren">Kjell N Gren</name><name sortKey="Rinne, Urpo K" sort="Rinne, Urpo K" uniqKey="Rinne U" first="Urpo K." last="Rinne">Urpo K. Rinne</name><name sortKey="Ruotsawnen, Ulla" sort="Ruotsawnen, Ulla" uniqKey="Ruotsawnen U" first="Ulla" last="Ruotsawnen">Ulla Ruotsawnen</name><name sortKey="Ruottinen, Hanna" sort="Ruottinen, Hanna" uniqKey="Ruottinen H" first="Hanna" last="Ruottinen">Hanna Ruottinen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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